July 1, 1988Journal of VirologyOpen Access

Identification of cross-reactive and serotype 2-specific neutralization epitopes on VP3 of human rotavirus

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Population

Human rotavirus

Design

Preclinical

Authors

KTK. TaniguchiShionogi (Japan)WMW L MaloyBoston University KNK NishikawaOsaka City University

Discussion

Member takes

Implication

May inform rotavirus vaccine design; hypothesis-generating from animal data only.

Structured PICO

Population

Human rotavirus (group A rotaviruses, antigenic mutants resistant to anti-VP3 neutralizing monoclonal antibodies)

Intervention

Sequencing the VP3 gene of antigenic mutants

Outcome

Identification of cross-reactive and serotype-specific neutralization epitopes on VP3surrogate

The identification of specific neutralization epitopes on the VP3 protein of human rotavirus provides structural insights that may aid in vaccine development.

Cite This Study

Taniguchi et al. (1988) studied this question.

synapsesocial.com/papers/69d8d8412c87b79b92d17dec https://doi.org/10.1128/jvi.62.7.2421-2426.1988

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Identification of cross-reactive and serotype 2-specific neutralization epitopes on VP3 of human rotavirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of cross-reactive and serotype 2-specific neutralization epitopes on VP3 of human rotavirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider