Demonstrates that estrogen inhibits vascular calcification by targeting the RANKL pathway via estrogen receptors, suggesting a protective mechanism against blood vessel hardening.
RANKL contributes to vascular calcification by regulating bone morphogenetic protein-2 and MGP expression, as well as bone-related proteins, and is counteracted by estrogen in a receptor-dependent manner.
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Osako et al. (2010) studied this question.
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