Base editing of the mutated TERT promoter inhibits liver tumor growth

This is the authors' abstract. We don't add key points for this paper.

These findings demonstrate that a sgRNA-guided CjABE efficiently converts the mutated TERT promoter -124 C>T to -124 C in HCC cells and underscore the potential to treat HCC by the base editing-mediated correction of TERT promoter mutations.