What is the long-term risk of cardiovascular disease mortality compared to cancer-specific mortality among classic Hodgkin lymphoma survivors?
Cardiovascular disease has become the leading cause of death over time among survivors of early-stage classic Hodgkin lymphoma, emphasizing the critical need for long-term cardiovascular risk management in this population.
Among patients with stage I and stage II classic Hodgkin lymphoma (cHL), the proportional mortality ratio of cardiovascular disease (CVD) exceeded that of cHL after approximately 60 or 120 months of follow-up, respectively. For almost all the patients with stage I or stage II disease, the cumulative incidence of CVD mortality exceeded that of cHL and other neoplasms over time. In the past several decades, the risk of cHL mortality declined sharply, but the risk of CVD mortality among patients with cHL declined quite slowly or even unchanged among some populations. CVD exceeded cHL and has become the leading cause of death over time.
Lu et al. (Mon,) studied this question.