Subnormal Levels of Glucose in Urine

Since the middle of the 19th century, it has been known that normal urine contains small quantities of glucose.¹⁻³Nevertheless, the present knowledge concerning the physiological range of urinary glucose concentrations is on the basis of only a few reports. Nagasaki⁴found the normal range to be 2 to 33 mg of glucose per 100 milliliters of urine in a study of 174 randomly selected cases. In specimens of morning urine Haller⁵recorded values from less than 3.1 to 12.5 mg/100 ml of urine in a small series. Using a glucose oxidase method, Fine⁶found the normal range in 740 individuals to be 1 to 15 mg/100 ml of urine. In his studies the urinary specimens were not collected in the fasting state. Renschler⁷used the hexokinase glucose-6-phosphate dehydrogenase method in an extensive study of urinary glucose in 159 individuals. He found the upper limit