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January 13, 2020Experimental Cell ResearchOpen Access

ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma

C. Persson Kristoffer von Stedingk Elina Fredlund Daniel Bexell Sven Påhlman Caroline Wigerup Sofie Mohlin

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Abstract

The lack of effect from PT2385 treatment in combination with high cytoplasmic HIF-2α expression at normoxia suggest that HIF-2α have additional roles than acting as an ARNT dependent transcription factor. It is important to further unravel the conditions at which HIF-2α has transcriptional and non-transcriptional roles in neuroblastoma.

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Persson et al. (2020) studied this question.

synapsesocial.com/papers/69d8ee78d2f7327e70ae4894 https://doi.org/10.1016/j.yexcr.2020.111845

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancerReview · 2016 · 717 citations
2Hypoxia-Inducible Factor-2α Correlates to Distant Recurrence and Poor Outcome in Invasive Breast CancerOriginal Research · 2008 · 133 citations
3Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survivalPrognostic Study · 2001 · 476 citations
4HIF-1α and HIF-2α Are Differentially Regulated <i>In vivo</i> in Neuroblastoma: High HIF-1α Correlates Negatively to Advanced Clinical Stage and Tumor VascularizationOriginal Research · 2009 · 76 citations
5Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotypeOriginal Research · 2002 · 399 citations

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