From the ethyl acetate-soluble fraction of the drug Eclipta alba (L.) Hassk. Asteraceae, besides a flavonoid and simple phenolcarboxylic acids, the coumestans wedelolactone and demethyl-wedelolactone were isolated as the main active principles. Both constituents exhibited antihepatotoxic activity in assays employing CCl4-, GalN-, and phalloidin-cytotoxicity in rat hepatocytes. They also showed a significant stimulatory effect on liver cell regeneration. A HPLC-method is described for qualitative and quantitative analysis of the coumestans, in the extracts of Eclipta alba and also Wedelia calendulacea Less., Asteraceae.
No takes yet. Share an insight, caveat, or question.
Wagner et al. (1986) studied this question.