Nickel‐Catalyzed Asymmetric Addition of Alkyne CH Bonds across 1,3‐Dienes Using Taddol‐Based Chiral Phosphoramidite Ligands

Enantioenriched 3-methyl-1,4-enynes are the products of the title reaction. The terminal α-siloxy-sec-alkyl groups were then converted into γ-oxoalkyl groups by rhodium-catalyzed conjugate alkynyl addition to α,β-unsaturated ketones through cleavage of the alkynyl CC bond.