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May 20, 2023Critical CareOpen Access

The lower limit of reactivity as a potential individualised cerebral perfusion pressure target in traumatic brain injury: a CENTER-TBI high-resolution sub-study analysis

Erta Beqiri Frederick A. Zeiler Ari Ercole Michał M. Placek Jeanette Tas Joseph E. Donnelly Marcel Aries Peter J. Hutchinson David K. Menon Nino Stocchetti Marek Czosnyka Peter Smielewski Audny Anke Ronny Beer Bo‐Michael Bellander Erta Beqiri András Büki Manuel Cabeleira Marco Carbonara Arturo Chieregato Giuseppe Citerio Hans Clusmann Endre Czeiter Marek Czosnyka Bart Depreitere Ari Ercole Shirin Frisvold Raimund Helbok Stefan Jankowski Daniel Kondziella Lars‐Owe Koskinen Ana Kowark David Menon Geert Meyfroidt Kirsten Moeller David Nelson Anna Piippo-Karjalainen Andreea Rădoi Arminas Ragauskas Rahul Raj Jonathan R. Rhodes Saulius Ročka Rolf Rossaint Juan Sahuquillo Oliver Sakowitz Peter Smielewski Nino Stocchetti Nina Sundström Riikka Takala Tomas Tamošuitis Olli Tenovuo Andreas Unterberg Peter Vajkoczy Alessia Vargiolu Rimantas Vilcinis Stefan Wolf Alexander Younsi Frederick A. Zeiler

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Abstract

Using a multicentre cohort, we confirmed that CPP below LLR was associated with mortality during the first seven days post injury.

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Cite This Study

Beqiri et al. (2023) studied this question.

synapsesocial.com/papers/69d8f23517a1cc0598d18e94 https://doi.org/10.1186/s13054-023-04485-8

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)Original Research · 2019 · 659 citations
2Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulationReview · 2021 · 925 citations
3Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injuryOriginal Research · 2002 · 781 citations
4Cerebral autoregulation following head injuryOriginal Research · 2001 · 347 citations
5Losing the dogmatic view of cerebral autoregulationReview · 2021 · 177 citations

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Association between Cerebrovascular Reactivity Monitoring and Mortality Is Preserved When Adjusting for Baseline Admission Characteristics in Adult Traumatic Brain Injury: A CENTER-TBI Study2019
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