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July 22, 2021Inflammatory Bowel Diseases

Visceral Adipose Tissue Volumetrics Inform Odds of Treatment Response and Risk of Subsequent Surgery in IBD Patients Starting Antitumor Necrosis Factor Therapy

Phillip Gu Avneesh Chhabra Punya Chittajallu Christopher Chang Denisse Mendez Andrew J. Gilman David Fudman Yin Xi Linda A. Feagins

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Abstract

We found VAT volume is associated with anti-TNF treatment response in a nondose dependent manner, and VFI may inform risk of surgery after anti-TNF initiation. If confirmed by prospective studies, VAT volumetrics are potentially useful biomarkers to inform IBD treatment decisions.

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Gu et al. (2021) studied this question.

synapsesocial.com/papers/69d8f26c2c87b79b92d18413 https://doi.org/10.1093/ibd/izab167

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Assessing Response and Loss of Response to Biological Therapies in IBDRisk Assessment · 2011 · 326 citations
2Prevalence of Inflammatory Bowel Disease Among Adults Aged ≥18 Years — United States, 2015Original Research · 2016 · 623 citations
3Obesity and response to anti-tumor necrosis factor-α agents in patients with select immune-mediated inflammatory diseases: A systematic review and meta-analysisRCT · 2018 · 293 citations
4Obesity and Response to Infliximab in Patients with Inflammatory Bowel Diseases: Pooled Analysis of Individual Participant Data from Clinical TrialsHuman Clinical Trial · 2018 · 65 citations
5Associations Between Obesity and the Effectiveness of Anti–Tumor Necrosis Factor-α Agents in Inflammatory Bowel Disease Patients: A Literature Review and Meta-analysisMeta-Analysis · 2020 · 49 citations

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