Mechanisms linking bariatric surgery to adipose tissue, glucose metabolism, fatty liver disease and gut microbiota

Saverio Latteri; Maria Sofia; Stefano Puleo; Angelica Di Vincenzo; Saverio Cinti; Sergio Castorina

doi:10.1007/s00423-023-02821-8

February 24, 2023Langenbeck s Archives of SurgeryOpen Access

Mechanisms linking bariatric surgery to adipose tissue, glucose metabolism, fatty liver disease and gut microbiota

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Key Points

Identify the mechanistic pathways through which bariatric surgery influences gut microbiota, adipose tissue, glucose homeostasis, and hepatic steatosis.
Review and synthesis of molecular and physiological pathways linking surgical gastrointestinal modifications to metabolic improvements.
Evaluation of interactions among gut microbial profiles, systemic lipid metabolism, and liver pathology.
Bariatric procedures remodel the composition and functional capacity of the gut microbiota.
Microbiota-mediated alterations in lipid metabolism drive the mitigation and improvement of non-alcoholic fatty liver disease.

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Implication

Review demonstrates how bariatric surgery alters gut microbiota in metabolic disease, indicating a key role in resolving fatty liver disease.

Abstract

Bariatric surgery modifies gut microbiota, and these modifications influence lipid metabolism, leading to improvement of non-alcoholic fatty liver disease.

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Cite This Study

Latteri et al. (2023) studied this question.

synapsesocial.com/papers/69d8f2a117a1cc0598d18f08 https://doi.org/10.1007/s00423-023-02821-8

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Mechanisms linking bariatric surgery to adipose tissue, glucose metabolism, fatty liver disease and gut microbiota

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Mechanisms linking bariatric surgery to adipose tissue, glucose metabolism, fatty liver disease and gut microbiota

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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