Why the study?
Does the extent, location, and pattern of Late Gadolinium Enhancement predict death and sudden cardiac death in patients with dilated cardiomyopathy?
Does the extent, location, and pattern of Late Gadolinium Enhancement predict death and sudden cardiac death in patients with dilated cardiomyopathy?
In patients with dilated cardiomyopathy, the presence of septal late gadolinium enhancement is a strong predictor of death and sudden cardiac death, with limited incremental prognostic value from the extent or pattern beyond small amounts.
May support incorporating septal LGE into DCM risk stratification; leaves open whether it should guide ICD decisions.
In DCM, the presence of septal LGE is associated with a large increase in the risk of death and SCD events, even when the extent is small. SCD risk is greatest with concomitant septal and free-wall LGE. The incremental value of LGE extent beyond small amounts and LGE pattern is limited.
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Halliday et al. (2018) studied this question.
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