September 1, 1996Clinical ChemistryOpen Access

Thrombus precursor protein (TpP): marker of thrombosis early in the pathogenesis of myocardial infarction

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Why the study?

Does the thrombus precursor protein (TpP) assay accurately identify active thrombosis in patients with early myocardial infarction?

Population

Patients recruited for the GUSTO intervention study and subjects presenting at the emergency room with chest…

Comparison

Thrombus precursor protein enzyme-linked… vs Control subjects and patients diagnosed without…

Design

Cross-sectional

Authors

DCDavid G.M. CarvilleIndiana University South Bend NDNikola DimitrijevićUniversity of Notre Dame MWMark WalshUniversity of Notre Dame

Discussion

Member takes

Implication

TpP elevation was associated with early MI; leaves open diagnostic utility as thrombosis marker pending prospective validation.

Structured PICO

Does the thrombus precursor protein (TpP) assay accurately identify active thrombosis in patients with early myocardial infarction?

Population

Patients recruited for the GUSTO intervention study (MI patients, patients without MI, controls) and subjects presenting at the emergency room with chest pain.

Intervention

Thrombus precursor protein (TpP) enzyme-linked immunosorbent immunoassay

Comparator

Control subjects and patients diagnosed without MI or presenting late

Outcome

Thrombus precursor protein (TpP) concentrationsurrogate

The thrombus precursor protein (TpP) assay can identify active thrombosis and may serve as a useful diagnostic aid for early myocardial infarction.

Cite This Study

Carville et al. (1996) studied this question.

synapsesocial.com/papers/69d8f61cade63f05b9bedfda https://doi.org/10.1093/clinchem/42.9.1537

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