Bilayer structural evolution of a single-tail nonionic surfactant cocodiethanolamide−water system is studied using cryo-transmission electron microscopy (cryo-TEM), small-angle X-ray scattering, light scattering, and rheological measurements. It is found that, with increasing surfactant concentration, unilamellar vesicles turn to multilamellar vesicles while at higher concentrations a fully expressed lamellar phase is clearly observed in the TEM micrographs. The results will be discussed in terms of surfactant geometry and membrane flexibility.
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Regev et al. (1999) studied this question.
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