What question did this study set out to answer?

To evaluate the potential therapeutic role of corticosteroids in the management of acute respiratory distress syndrome given their anti-inflammatory utility in related critical conditions.

May 8, 2023Journal of Clinical MedicineOpen Access

Corticosteroids in ARDS

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Authors

EKEmmanuelle KupermincUniversité de Versailles Saint-Quentin-en-Yvelines NHNicholas HemingInserm MCMiguel CarlosAssistance Publique – Hôpitaux de Paris

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Implication

Narrative review explores therapeutic benefits of corticosteroids in acute respiratory distress syndrome, highlighting the need for definitive dosing and timing protocols.

Key Points

To evaluate the potential therapeutic role of corticosteroids in the management of acute respiratory distress syndrome given their anti-inflammatory utility in related critical conditions.
Conducted a narrative review of English-language publications indexed in PubMed prior to January 2023 using search terms acute respiratory distress syndrome, sepsis, and steroids.
Identified supplementary evidence via reference screening of retrieved articles and subject-matter expert knowledge.
Corticosteroids exert potent anti-inflammatory effects that mitigate mortality in severe community-acquired pneumonia and are established standard interventions in septic shock and severe COVID-19 respiratory failure.
A biological rationale supports corticosteroid efficacy in acute respiratory distress syndrome due to shared inflammatory mechanisms with sepsis, though optimal clinical dosing, timing, and treatment duration remain unconfirmed.

Cite This Study

Kuperminc et al. (2023) studied this question.

synapsesocial.com/papers/69d8fe3bb305d713c2bed8ff https://doi.org/10.3390/jcm12093340

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Implication

Narrative review explores therapeutic benefits of corticosteroids in acute respiratory distress syndrome, highlighting the need for definitive dosing and timing protocols.

Corticosteroids in ARDS

Discussion

Member takes

Implication

Key Points

Cite This Study

Corticosteroids in ARDS

Discussion

Member takes

Implication

Key Points

Cite This Study

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