Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study

The findings suggest that paternal use of metformin during the period of sperm development is not associated with congenital malformations in offspring, including organ specific malformations. Metformin can therefore continue to be considered a suitable initial oral agent for managing glucose levels in men with type 2 diabetes mellitus who plan on having children.