Why the study?
Does metformin prevent or slow down the onset of type 2 diabetes in women with PCOS and prediabetes?
Does metformin prevent or slow down the onset of type 2 diabetes in women with PCOS and prediabetes?
High prevalence of prediabetes in women with PCOS warrants mandatory screening and potential metformin use to delay type 2 diabetes onset.
May support prediabetes screening in PCOS; leaves open metformin efficacy pending randomized trials.
The emergence of prediabetes is significantly correlated with insulin resistance as confirms the impact of the insulin resistance degree to the emergence of prediabetes. Knowledge about the existence of high prediabetes prevalence in women with PCOS will help in the decision on mandatory screening, more prompt diagnosis and treatment, which could prevent or delay the onset of the formation of clinically manifested diabetes. Prediabetes can be a reversible process with improved metabolic control and the use of metformin in prediabetes in women with PCOS may prevent or slow down the onset of type 2 diabetes.
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Ibricevic et al. (2013) studied this question.
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