Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

Hongtu Cui; Yanghui Chen; Ke Li; Rui Zhan; Mingming Zhao; Yangkai Xu; Zhiyong Lin; Yi Fu; Qihua He; Paul C. Tang; Ienglam Lei; Jifeng Zhang; Chenze Li; Yang Sun; Xinhua Zhang; Tiffany Horng; Hong Lü; Y. Eugene Chen; Alan Daugherty; Dao Wen Wang; Lemin Zheng

doi:10.1093/eurheartj/ehab605

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Abstract

Plasma succinate concentrations allow to distinguish patients with AAD from both healthy controls and patients with AMI or PE. Succinate concentrations are regulated by the p38α-CREB-OGDH axis in macrophages.

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Cui et al. (2021) studied this question.

synapsesocial.com/papers/69d9045dbfc0898f4bd17e83 https://doi.org/10.1093/eurheartj/ehab605

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Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

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Abstract

Discussion

Cite This Study

Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

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Abstract

Discussion

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