Succinate induces pathological cardiomyocyte hypertrophy via GPR91 activation, providing a mechanism for ischemia-induced hypertrophic cardiomyopathy.
Preclinical data implicate GPR91 in hypertrophy; human studies needed before considering therapeutic targeting.
These results show for the first time that succinate plays an important role in cardiomyocyte hypertrophy through GPR91 activation, and extend our understanding of how ischemia can induce hypertrophic cardiomyopathy.
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Aguiar et al. (2014) studied this question.
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