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March 25, 2006AJP Heart and Circulatory Physiology217 citations

DNA damage is an early event in doxorubicin-induced cardiac myocyte death

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Why the study?

Does doxorubicin induce DNA damage leading to cell death in H9c2 cardiac myocytes?

Population

H9c2 cardiac myocytes

Comparison

Doxorubicin at clinically relevant concentrations vs Control (untreated) and H2O2-treated myocytes

Design

Preclinical

Authors

TLThomas J. L’EcuyerSSSanjeev SanjeevRTRonald Thomas

Discussion

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Overview

Suggests p53-mitochondrial pathway as doxorubicin cardiotoxicity target; leaves open clinical translation pending human validation.

Structured PICO

Does doxorubicin induce DNA damage leading to cell death in H9c2 cardiac myocytes?

P
Population
H9c2 cardiac myocytes
I
Intervention
Doxorubicin at clinically relevant concentrations
C
Comparator
Control (untreated) and H2O2-treated myocytes
O
Outcome
DNA damage assessed using the alkaline comet assaysurrogate

Doxorubicin-induced cardiotoxicity involves early DNA damage leading to cell death via a p53 and mitochondrial-dependent pathway.

Cite This Study

L’Ecuyer et al. (2006) studied this question.

synapsesocial.com/papers/69d905e0bfc0898f4bd17f88https://doi.org/10.1152/ajpheart.00738.2005
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