Animal study demonstrates that estrogen promotes Th2 cytokine production and eosinophil localization during allergen exposure in mice, suggesting hormonal modulation of asthma pathology.
These data show that during aeroallergen challenge, estrogen stimulates Th2 cytokine production, which may be linked to its ability to suppress 12-HETE. Lung resistance at baseline, goblet cell hyperplasia and the compartmentalisation of eosinophils was also influenced by estrogen. However, estrogen does not play a major role in stimulating enhanced sensitivity to methacholine-induced lung resistance.
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Cai et al. (2012) studied this question.
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