Narrative review highlights therapeutic roles of ITK inhibition in T cell disorders, suggesting broad utility across allergy, autoimmunity, and oncology.
The focus of this review is to examine the role of ITK signaling in multiple diseases and investigate the clinical potential of ITK inhibition. The diseases and potential interventions reviewed include T cell-derived malignancies as well as other neoplastic diseases, allergic diseases such as asthma and atopic dermatitis, certain infectious diseases, several autoimmune disorders such as rheumatoid arthritis and psoriasis, and finally the use of ITK inhibition in both solid organ and bone marrow transplantation recipients.
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Weeks et al. (2021) studied this question.
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