Cell-based strategies for rotator cuff repair may need to be combined with growth and differentiation factors to achieve effective tendon-to-bone healing.
Cell-based strategies may fall short alone for rotator cuff healing; leaves open combined growth factor approaches for prospective trials.
A biologic solution to the problem of tendon-to-bone healing in the rotator cuff remains elusive. The repair site may lack the cellular and/or molecular signals necessary to induce appropriate differentiation of transplanted cells. Further studies are needed to determine if cell-based strategies need to be combined with growth and differentiation factors to be effective.
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Gulotta et al. (2009) studied this question.
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