Why the study?
Links between Lp(a) and stroke are less consistent than for coronary heart disease, and Blacks have higher Lp(a) levels and stroke incidence but have been underrepresented in studies.
Does elevated Lipoprotein(a) increase the risk of incident ischemic stroke in black and white US adults?
Population
572 incident ischemic stroke cases and a 967-person cohort random sample from 30 239 US adults aged ≥45
Comparison
Fourth vs first baseline Lp(a) quartile
Design
Prospective cohort study case-cohort analysis
Authors
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Lp(a) quartile was weakly associated with ischemic stroke, stronger in blacks; hypothesis-generating and should not yet change practice.
Does elevated Lipoprotein(a) increase the risk of incident ischemic stroke in black and white US adults?
Elevated Lipoprotein(a) is a risk factor for ischemic stroke, with evidence suggesting the risk multiplier may be more pronounced in black adults.
Arora et al. (2019) studied this question.
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