Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study

Anna Rautanen; Tara C. Mills; Anthony Gordon; Paula Hutton; Michael Steffens; Rosamond Nuamah; Jean‐Daniel Chiche; Tom Parks; S. Jonathan Chapman; Emma E. Davenport; Katherine S. Elliott; Julian Bion; Peter Lichtner; Thomas Meitinger; Thomas F. Wienker; Mark J. Caulfield; Charles A. Mein; Frank Bloos; Ilona Bobek; Paolo Cotogni; Vladimír Šrámek; Silver Sarapuu; Makbule Kobilay; V. Marco Ranieri; Jordi Rello; Gonzalo Sirgo; Yoram Weiss; Stefan Rußwurm; E. Marion Schneider; Konrad Reinhart; Paul Holloway; Julian C. Knight; Chris Garrard; James A. Russell; Keith R. Walley; Frank Stüber; Adrian V. S. Hill; Charles Hinds

doi:10.1016/s2213-2600(14)70290-5

Key Points

Identify common genetic variants associated with survival outcomes in individuals suffering from sepsis secondary to pneumonia.
Conducted an observational cohort study across clinical cohorts presenting with pneumonia-induced sepsis.
Performed a genome-wide association scan to correlate single-nucleotide polymorphisms with patient mortality.
Identified candidate genomic loci that associate with differential survival rates in critical lung-derived sepsis.
Highlighted specific biological pathways linked to the immune and inflammatory response affecting disease prognosis.

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Implication

Observational cohort study uncovers genetic determinants of survival in sepsis caused by pneumonia, highlighting biological mechanisms influencing mortality.

Abstract

European Commission and the Wellcome Trust.

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Rautanen et al. (2014) studied this question.

synapsesocial.com/papers/69d91da39402b8412aa3c36d https://doi.org/10.1016/s2213-2600(14)70290-5

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Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study

Key Points

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Implication

Abstract

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Cite This Study

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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