Do second-generation antipsychotics reduce tardive dyskinesia risk compared to first-generation antipsychotics?
Second-generation antipsychotics carry a lower risk of tardive dyskinesia than first-generation agents, though the risk remains clinically relevant.
Current evidence supports a lower tardive dyskinesia risk for second-generation antipsychotics than for first-generation antipsychotics. Tardive dyskinesia incidence was higher with second-generation antipsychotics than previously reported, possibly due to recent studies with relatively short mean durations and use of nonstandard tardive dyskinesia definitions.
Correll et al. (2008) studied this question.