Identifies potential mechanisms by which protein aggregation and PSEN1 variants affect cardiac function in idiopathic dilated cardiomyopathy.
On the basis of these findings, we propose that 2 mechanisms may link protein aggregation and cardiac function: oligomer-induced changes on Ca(2+) handling and a direct effect of PSEN1 sequence variants on excitation-contraction coupling protein function.
Gianni et al. (Tue,) studied this question.