Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot

Miriam S. Reuter; Rebekah Jobling; Rajiv Chaturvedi; Roozbeh Manshaei; Gregory Costain; Tracy Heung; Meredith Curtis; S. Mohsen Hosseini; Eriskay Liston; Chelsea Lowther; Erwin Oechslin; Heinrich Sticht; Bhooma Thiruvahindrapuram; Spencer van Mil; Rachel M. Wald; Susan Walker; Christian R. Marshall; Candice K. Silversides; Stephen W. Scherer; Raymond H. Kim; Anne S. Bassett

doi:10.1038/s41436-018-0260-9

Abstract

Loss-of-function variants in FLT4 and KDR contribute substantially to the genetic basis of TOF. The findings support dysregulated VEGF signaling as a novel mechanism contributing to the pathogenesis of TOF.

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Reuter et al. (2018) studied this question.

synapsesocial.com/papers/69d9254ada3af5b1d0835ccc https://doi.org/10.1038/s41436-018-0260-9

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Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot

Abstract

Discussion

Cite This Study

Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot

Abstract

Discussion

Cite This Study

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