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Vancomycin fu after UF at 4°C was on average 30.6% lower than that after UF at 37°C, demonstrating the importance of temperature during UF. Ultrafiltration at 37°C resulted in unbound vancomycin concentrations equivalent with ED. As the unbound concentration could be reliably predicted based on total vancomycin concentrations as such, measurement of unbound vancomycin concentrations has little added value over measurements of total vancomycin concentrations.
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Stove et al. (2014) studied this question.
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