Does immunoassay inaccuracy affect the validity of the saline infusion test for diagnosing primary aldosteronism?
Immunoassay inaccuracy significantly compromises the validity of the saline infusion test for diagnosing primary aldosteronism, potentially leading to misdiagnosis in a majority of patients with presumed bilateral disease.
These findings raise concerns about the validity of immunoassay-based diagnosis of PA in over 60% of patients with presumed bilateral disease. We provide a simple solution to minimize immunoassay inaccuracy-associated misdiagnosis of PA.
Eisenhofer et al. (Tue,) studied this question.