Animal study reveals that inhibiting p38 MAP kinase blunts infarct size reduction from ischemic preconditioning in pigs, indicating an essential protective role for this signaling pathway.
The attenuation of the IS-reducing effect of IP depends on the effectiveness of blockade of p38MAPK activity. p38MAPK is a mediator of IP in pigs.
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Rainer Schulz (2002) studied this question.
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