Why the study?
Is a family history of premature coronary heart disease associated with the presence and extent of coronary artery calcification?
Is a family history of premature coronary heart disease associated with the presence and extent of coronary artery calcification?
A family history of premature coronary heart disease, particularly a sibling history, is strongly associated with subclinical coronary atherosclerosis as measured by coronary artery calcification.
Our study demonstrates a highly significant association between FH of premature CHD and the presence and extent of CAC. Furthermore, within the limits of self-reporting of family history, our findings suggest that a sibling history is more strongly associated with subclinical coronary atherosclerosis than a parental history of premature CHD.
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Nasir et al. (2004) studied this question.
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