October 5, 2004Circulation175 citationsOpen Access
View Full PaperCoronary Artery Calcification and Family History of Premature Coronary Heart Disease
Structured PICO
Is a family history of premature coronary heart disease associated with the presence and extent of coronary artery calcification?
I
Intervention
Family history of premature coronary heart disease (sibling or parental)
C
Comparator
No family history of premature coronary heart disease
O
Outcome
Presence and extent of coronary artery calcification (CAC)surrogate
A family history of premature coronary heart disease, particularly a sibling history, is strongly associated with subclinical coronary atherosclerosis as measured by coronary artery calcification.
Abstract
Our study demonstrates a highly significant association between FH of premature CHD and the presence and extent of CAC. Furthermore, within the limits of self-reporting of family history, our findings suggest that a sibling history is more strongly associated with subclinical coronary atherosclerosis than a parental history of premature CHD.