Key points are not available for this paper at this time.
We report the first neutral and water-soluble polymer capable of strong mitochondrial targeting in vitro and in vivo, zwitterionic poly2-(N-oxide-N,N-diethylamino)ethyl methacrylate (OPDEA). OPDEA is quickly internalized via macropinocytosis by various cancer cells and transferred into the mitochondria, which slightly lowers the mitochondrial membrane potential as determined by the JC-1 assay.
Geng et al. (Tue,) studied this question.