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August 16, 2010PLoS ONE176 citationsOpen Access

Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells

AKAnn H. KloppLLLara LacerdaAGAnshul Gupta

Key Points

  • The aim is to investigate the role of mesenchymal stem cells (MSC) in mammosphere formation and E-cadherin expression in breast cells.
  • Examined primary mammosphere formation in normal and malignant breast cells with MSC involvement.
  • Measured E-cadherin expression levels associated with cancer progression.
  • MSC significantly increase the efficiency of mammosphere formation in both normal and malignant cells.
  • MSC decrease E-cadherin expression, indicating a potential link to breast cancer progression.

Abstract

MSC increase the efficiency of primary mammosphere formation in normal and malignant breast cells and decrease E-cadherin expression, a biologic event associated with breast cancer progression and resistance to therapy.

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Cite This Study

Klopp et al. (2010) studied this question.

synapsesocial.com/papers/69d946e49402b8412aa3cca2https://doi.org/10.1371/journal.pone.0012180
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