Genetic Characteristics of Cutaneous, Acral, and Mucosal Melanoma in Japan

This is the authors' abstract. We don't add key points for this paper.

This study highlights distinct genetic abnormalities and actionable alterations in Japanese melanoma patients. This suggests a lower tumor mutational burden in East Asian cutaneous melanoma, which may affect the efficacy of immune checkpoint inhibitors. The heterogeneity of driver mutations across and within individuals highlights the need for personalized treatment approaches.