Why the study?
Does intravenous fat emulsion therapy improve outcomes in patients with life-threatening flecainide overdose?
Does intravenous fat emulsion therapy improve outcomes in patients with life-threatening flecainide overdose?
Intravenous fat emulsion should be considered as a novel adjunctive therapy in patients with life-threatening toxicity following flecainide overdose.
May support intravenous fat emulsion in refractory flecainide toxicity; hypothesis-generating case report requiring prospective validation.
Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life-threatening cardiac toxicity in overdose. The cornerstone of treatment is fluid resuscitation and the administration of magnesium and sodium bicarbonate. We report a case of flecainide overdose associated with life-threatening hemodynamic compromise successfully treated with intravenous fat emulsion (IFE) therapy. IFE should be considered as a novel adjunctive therapy in patients with life-threatening toxicity following flecainide overdose.
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Ellsworth et al. (2012) studied this question.
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