What question did this study set out to answer?

To examine the mechanisms by which Prevotella species colonize mucosal surfaces, modulate host immune pathways, and contribute to localized and systemic chronic inflammatory conditions.

May 23, 2017ImmunologyOpen Access

The immune response to Prevotella bacteria in chronic inflammatory disease

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To examine the mechanisms by which Prevotella species colonize mucosal surfaces, modulate host immune pathways, and contribute to localized and systemic chronic inflammatory conditions.
Synthesis of human genetic sequencing studies linking mucosal Prevotella abundance to inflammatory and metabolic disorders.
Review of in vitro mechanistic experiments evaluating receptor activation and cytokine secretion.
Evaluation of gnotobiotic and colonized mouse models assessing disease phenotypes following Prevotella exposure.
Increased mucosal abundance of Prevotella is associated with periodontitis, bacterial vaginosis, rheumatoid arthritis, and metabolic disorders, but is reduced in the lungs of patients with asthma and chronic obstructive pulmonary disease.
Prevotella engages Toll-like receptor 2 on antigen-presenting cells to trigger the release of Th17-polarizing cytokines (IL-23, IL-1) and stimulates epithelial cells to produce IL-6, IL-8, and CCL20 for neutrophil recruitment.
Mouse colonization models confirm that Prevotella promotes disease-like mucosal inflammation, leading to systemic circulation of inflammatory mediators and bacterial products.

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Implication

Literature review reveals mucosal and systemic inflammatory mechanisms driven by Prevotella species, highlighting their potential role as pathobionts in chronic disease.

Cite This Study

Jeppe Madura Larsen (2017) studied this question.

synapsesocial.com/papers/69d94bb87fca1f84ab684940 https://doi.org/10.1111/imm.12760

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Implication

Literature review reveals mucosal and systemic inflammatory mechanisms driven by Prevotella species, highlighting their potential role as pathobionts in chronic disease.

The immune response to Prevotella bacteria in chronic inflammatory disease

Key Points

Discussion

Implication

Cite This Study

The immune response to Prevotella bacteria in chronic inflammatory disease

Key Points

Discussion

Implication

Cite This Study

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