Cancer risk in patients with psoriasis: should we be paying more attention?

Patients with psoriasis have an increased risk of cancers overall and some site-specific cancers especially non-melanoma skin cancer, lymphoma, and lung cancer. The increased risk is most likely due to a combination of the chronic low-grade inflammation in psoriasis, risk factors for cancer associated with psoriasis, and the treatment of psoriasis. Future research should investigate the contribution of the individual mechanisms. Additionally, multiple new specific immunomodulatory treatments for psoriasis have been introduced during recent years and it is important to monitor and investigate whether these treatments confer an increased risk of cancers. Lastly, as patients with psoriasis have an increased alcohol use, smoke more than the general population and as psoriasis has been linked to obesity, promotion of a healthy lifestyle is key in the prevention of certain cancer types.