A new synthon involving carboxylic acid and a secondary amide with anti geometry has been identified and used as a designing element to engineer the cocrystals of symmetrically substituted triamides, tricarboxylic acids, and aromatic guest molecules. The robustness of the synthon has been explored by considering the pyridine functional groups in the amide molecules.
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Rajput et al. (2008) studied this question.
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