Key result
History of dysphoria and major depressive episodes is linked to increased MI risk.
Why the study?
The relationship between depression, psychotropic medication use, and risk of myocardial infarction was unclear.
Does a history of depression or psychotropic medication use increase the risk of myocardial infarction?
Does a history of depression or psychotropic medication use increase the risk of myocardial infarction?
Depression is associated with an increased risk of myocardial infarction, and the apparent risk associated with psychotropic medications is likely confounded by the underlying depression.
Depression history may elevate MI risk; leaves open causality and whether treatment modifies outcomes in prospective trials.
These data suggest that a history of dysphoria and a major depressive episode increase the risk of MI. The association between psychotropic medication use and MI is probably a reflection of the primary relationship between depression and MI.
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Pratt et al. (1996) studied this question. A history of dysphoria and major depressive episodes increases the risk of myocardial infarction, with psychotropic medication use likely reflecting this primary relationship.
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