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February 25, 2010Journal of Biological ChemistryOpen Access

Overexpression of periostin promoted the proteolytic cleavage of the LOX propeptide, increasing active LOX protein through interaction with BMP-1.

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Population

Calvarial osteoblast cells derived from periostin null mice

Comparison

Overexpression of periostin vs Periostin null cells

Design

Preclinical

Authors

TMTakumi MaruhashiIKIsao KiiMSMitsuru Saito

Discussion

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Overview

May inform post-MI ECM remodeling research; leaves open human translation from animal data.

Structured PICO

P
Population
Calvarial osteoblast cells derived from periostin null mice
I
Intervention
Overexpression of periostin
C
Comparator
Periostin null cells
O
Outcome
Proteolytic cleavage of LOX propeptide and amount of active LOX proteinsurrogate

Periostin supports BMP-1-mediated proteolytic activation of LOX on the extracellular matrix, promoting collagen cross-linking, which may have implications for tissue remodeling in infarcted myocardium and other connective tissues.

Cite This Study

Maruhashi et al. (2010) studied this question.

synapsesocial.com/papers/69d95a7094760e72e6a3c01chttps://doi.org/10.1074/jbc.m109.088864
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Also Consider

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