Why the study?
Whipple's disease is increasingly recognized as an important cause of culture-negative endocarditis despite classically presenting with gastrointestinal manifestations.
What are the clinical characteristics, common presentations, and outcomes of patients with Tropheryma whipplei endocarditis?
What are the clinical characteristics, common presentations, and outcomes of patients with Tropheryma whipplei endocarditis?
Whipple's disease is an increasingly recognized cause of culture-negative endocarditis that predominantly affects middle-aged men, often presents with heart failure or articular symptoms, and carries a high mortality rate of 24%.
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Informs recognition of Whipple endocarditis in culture-negative cases; observational synthesis leaves open standardized treatment protocols.
McGee et al. (2018) studied this question.
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