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October 26, 2022JAMAOpen Access

Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation

Naomi Hammond John Myburgh Ian Seppelt Tessa Garside Ruan Vlok Sajeev Mahendran Derick Adigbli Simon Finfer Ya Gao Fiona Goodman Gordon Guyatt Joseph Alvin Santos Balasubramanian Venkatesh Liang Yao Gian Luca Di Tanna Anthony Delaney

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Abstract

Among adults in the ICU treated with mechanical ventilation, the use of SDD compared with standard care or placebo was associated with lower hospital mortality. Evidence regarding the effect of SDD on antimicrobial resistance was of very low certainty.

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Hammond et al. (2022) studied this question.

synapsesocial.com/papers/69d95ed804deaa6ab568421d https://doi.org/10.1001/jama.2022.19709

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Surviving Sepsis CampaignOriginal Research · 2013 · 9,707 citations
2Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021Meta-Analysis · 2021 · 2,897 citations
3Ecological Effects of Selective Decontamination on Resistant Gram-negative Bacterial ColonizationCohort Study · 2009 · 225 citations
4Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated PatientsOriginal Research · 2018 · 180 citations
5Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical VentilationRCT · 2022 · 115 citations

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