Understanding Heterogeneity in Clinical Cohorts Using Normative Models: Beyond Case-Control Studies

This is the authors' abstract. We don't add key points for this paper.

Normative modeling provides a natural framework to study disorders at the individual participant level without dichotomizing the cohort. Instead, disease can be considered as an extreme of the normal range or as-possibly idiosyncratic-deviation from normal functioning. It also enables inferences over the degree to which behavioral variables, including diagnostic labels, map onto biology.