January 21, 2011Open Access

Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet

CTChek Kun TanNanyang Technological University NLNicolas LeuenbergerUniversity Centre of Legal Medicine MTMing TanQingdao University

Structured PICO

Population

Mice on a high-fat diet

Intervention

Smad3 deficiency

Outcome

Insulin resistance and obesitysurrogate

Smad3 deficiency protects mice against high-fat diet-induced obesity and insulin resistance, suggesting it as a potential therapeutic target.

Abstract

Smad3 is a multifaceted regulator in adipose physiology and the pathogenesis of obesity and type 2 diabetes, suggesting that Smad3 may be a potential target for the treatment of obesity and its associated disorders.

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Cite This Study

Tan et al. (Fri,) studied this question.

synapsesocial.com/papers/69d965e794760e72e6a3c4b5 https://doi.org/https://doi.org/10.2337/db10-0801

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