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November 2, 2021Biomedicine & PharmacotherapyOpen Access

Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction

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Why the study?

Cardiovascular comorbidities are pervasive in COPD, and this study explored the effect of lung microvascular barrier dysfunction on atherosclerosis in COPD and the potential protective mechanisms of Tongxinluo.

Does Tongxinluo prevent atherosclerosis progression and pulmonary microvascular barrier dysfunction in a model of COPD complicated with atherosclerosis?

Population

Mice with cigarette smoke and high-fat diet-induced COPD complicated with atherosclerosis, and HPMECs

Comparison

Atorvastatin vs Tongxinluo vs combination therapy (ATO+TXL)

Design

In vivo animal and in vitro cell experimental study

Follow-up

20 weeks

Authors

YWYafen WangWuhan UniversityXKXiangnan KuangHebei University of Chinese MedicineYYYujie YinHebei Medical University

Discussion

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Implication

Should not change practice; hypothesis-generating for Tongxinluo in COPD-atherosclerosis overlap models.

Structured PICO

Does Tongxinluo prevent atherosclerosis progression and pulmonary microvascular barrier dysfunction in a model of COPD complicated with atherosclerosis?

P
Population
Mice with COPD complicated with atherosclerosis induced by cigarette smoke (CS) exposure and high-fat diet (HFD) feeding; human pulmonary microvascular endothelial cells (HPMECs) incubated with cigarette smoke extract (CSE) and homocysteine (Hcy).
I
Intervention
Tongxinluo (TXL), atorvastatin (ATO), or combination therapy (ATO+TXL) for 20 weeks (in vivo); TXL pretreatment for 4 h (in vitro).
C
Comparator
Untreated disease models (CS+HFD mice; CSE+Hcy HPMECs).
O
Outcome
Pulmonary function, lung pathology, serum lipid levels, atherosclerotic plaque area, and indicators of barrier function, oxidative stress, and ferroptosis.surrogate

Tongxinluo delays atherosclerosis progression in a preclinical model of COPD by protecting the pulmonary microvascular barrier and inhibiting ferroptosis.

Cite This Study

Wang et al. (2021) studied this question.

synapsesocial.com/papers/69d9686b04deaa6ab568464fhttps://doi.org/10.1016/j.biopha.2021.112367
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