Why the study?
Does knockout of Adamts7 reduce atherosclerosis in mice?
Does knockout of Adamts7 reduce atherosclerosis in mice?
In vivo experimental validation demonstrates that Adamts7 is proatherogenic, suggesting that its pharmacological inhibition could be a novel therapeutic target for coronary artery disease.
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Adamts7 inhibition merits exploration as a CAD target; leaves open translation from murine models to humans.
Bauer et al. (2015) studied this question.
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