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May 24, 2006Investigative Ophthalmology & Visual Science

Proteomics Implicates Peptidyl Arginine Deiminase 2 and Optic Nerve Citrullination in Glaucoma Pathogenesis

Sanjoy K. Bhattacharya John S. Crabb Vera L. Bonilha Xiaorong Gu Hidenari Takahara John W. Crabb

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Abstract

Current results support translational modulation of PAD2 expression and a possible role for the enzyme in POAG optic nerve damage through citrullination and structural disruption of myelination.

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Bhattacharya et al. (2006) studied this question.

synapsesocial.com/papers/69d972131ad561c67368443e https://doi.org/10.1167/iovs.05-1499

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