Review reveals the dual pro- and anti-tumor roles of IFN-γ in the tumor microenvironment, highlighting the need to identify responsive patients to optimize immunotherapy.
Significant research efforts are required to decipher IFN-γ-dependent pro- and anti-tumorigenic effects. This review discusses the current knowledge concerning the roles of IFN-γ in the TME as a part of the complex immune response to cancer and highlights the importance of identifying IFN-γ responsive patients to improve their sensitivity to immuno-therapies.
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Jorgovanović et al. (2020) studied this question.
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