Uterus transplantation (UTx) has evolved as an effective treatment for women with absolute uterine-factor infertility (AUFI). From its tentative beginnings, this approach now has demonstrated success in two published multicentre reports – with a combined 78 recipients and 40 live births. Clinical and ethical considerations remain, with the requirement for a specialised multidisciplinary team to guide patient care as the procedure transitions from experimentation to a more widely accepted treatment reality. The majority of recipients are women with a congenitally absent uterus, receiving grafts predominantly from living donation, but as the procedure is adopted more broadly an expansion in both donor and recipient selection is anticipated. The goal of this review is to describe the current status of UTx, including an exploration of surgical technique, postoperative complications, graft and pregnancy assessment, and long-term outcomes. The review concludes with an optimistic outlook for the future of UTx, with an emphasis on the need for ongoing patient protection through regulatory oversight and long-term outcome reporting.
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Jacques et al. (2024) studied this question.
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